![]() Metabolic virtual biopsy of the myocardium for identification of specific patterns of intracellular lipid composition and myocardial glycogen metabolism as possible critical determinants of metabolic cardiomyopathy.the relative abundance of saturated and unsaturated fatty acids, and impaired myocardial glycogen metabolism may play an important role in the development cardiac lipotoxicity leading to diabetic cardiomyopathy. In addition to total ectopic lipid deposition in the myocardium, myocardial lipid composition, i.e. Due to methodological limitations so far data on myocardial glycogen stores and myocardial lipid composition in humans are missing. Data from animal experiments suggest a relevant role of myocardial glycogen stores in ischemic preconditioning. In addition carbohydrates stored as glycogen in muscle cells serve as readily available energy supply for contracting muscle. Thus, altered lipid composition might play an important role in genesis of diabetic cardiomyopathy and heart failure in diabetic patients. Recent studies suggest that not fat per se, but the content of saturated or unsaturated fatty acids might predict the development of cardiac steatosis and myocardial dysfunction. However, the association between intracellular lipid accumulation and (myocardial) functional impairment is likely more complex than originally imagined. Recent evidence suggests that increased myocardial lipid accumulation might contribute to the development of myocardial dysfunction by direct toxic effects (lipotoxicity). Ectopic intracellular lipid accumulation and impaired glycogen metabolism in skeletal muscle and liver are closely associated with metabolic impairment in insulin resistant subjects and patients with diabetes mellitus. ![]() Type 2 diabetes mellitus is a main risk factor for cardiovascular disease and heart failure, in part due to diabetic cardiomyopathy. A Cross Sectional Magnetic Resonance Spectroscopy and Imaging Study Myocardial lipid and glycogen metabolism in prediabetic and type 2 diabetic patients.
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